When a fire rips through the Venetian Arsenal in 1569, the enigmatic Emanuele De Zante, spy-catcher and secret agent, is betrayed by his lover, imprisoned, and accused of treason. Given the chance to escape, he embarks on a trans-European odyssey that will test his loyalty and force him to question even his own identity.Through a series of deadly political games leading all the way to the Sultan’s palace in Constantinople, De Zante and his companions spiral headfirst toward a conflict in which the great empires of the Republic of Venice and the Ottomans threaten the very foundations of civilization.

In Hollywood, Cary Grant has grown weary of cinema's constant glamour, but Her Majesty's Secret Service will break his malaise with a bizarre diplomatic mission. In Naples, Lucky Luciano fixes horse races and launches the global heroin trade. And in Bologna, a bartender searches for true love and his missing communist father.Set during the height of the Cold War-with the world divided into East and West-54 features Italian partisans, KGB agents, Parisian lowlifes, and cameos by David Niven, Marshal Tito, and Grace Kelly. Wu Ming brings us a cinematic romp that is by turns edgy social satire and modern comic send up.